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. 2021 Apr 27;9(7):e14808. doi: 10.14814/phy2.14808

FIGURE 2.

FIGURE 2

Drp1 activity and protein expression of mitochondrial quality control markers in skeletal muscle from mice either fed a LFD or HFD with or without Mdivi‐1 treatment. (a) Drp1 phosphorylations; (b) Ratio of Drp1 in the mitochondria fraction and whole tissue Drp1; (c) Correlation with the Drp1 translocation to mitochondria and blood glucose area under the curve (AUC) during GTT test (r = 0.566, p = 0.021). (d) Representative images of Drp1 colocalization with the mitochondrial marker COX IV in a section of skeletal muscle; (e) Quantification of Drp1 colocalization with the mitochondrial marker COX IV (n = 2–3); (f) Expression of regulatory proteins related to mitochondrial quality control; (g) Representative immunoblots for (e). Data are presented as mean ± SEM. n = 5–9/group. # p < 0.05 versus HFD