TABLE 1.
IC50 values for spironolactone and metabolite canrenoate on L. amazonensis and L. infantum promastigotes and intracellular amastigotes and CC50 values for murine peritoneal macrophages and the selectivity index (SI).
| Murine macrophage CC50 (µM) | L. amazonensis | L. infantum | |||||
|---|---|---|---|---|---|---|---|
| Promastigote IC50 (µM) | Amastigote IC50 (µM) | SI | Promastigote IC50 (µM) | Amastigote IC50 (µM) | SI | ||
| Spironolactone | 150.0 ± 3.4 | 3.6 ± 1.0 | 1.8 ± 0.7 | 83.3 | 28.6 ± 2.2 | 18.0 ± 1.1 | 8.3 |
| Canrenoate | >256 | >128 | 7.6 ± 2.3 | >34.6 | NT | NT | — |
Values represent the mean ± SE of three different experiments. NT–not tested.