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. 2021 Apr 23;218(6):e20210008. doi: 10.1084/jem.20210008

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© 2021 Li et al.

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Figure 2. — Ntn^loxP/loxP Lyz2 Cre⁺ mice have severe injury after myocardial IR surgery. (A) Experimental strategy for myocardial IR model. (B) Infarct sizes of Myosin Cre⁺ mice compared with Ntn1^loxP/loxP Myosin Cre⁺ mice after IR surgery (n = 6 for Myosin Cre⁺, n = 5 for Ntn1^loxP/loxP Myosin Cre⁺; two-tailed unpaired t test). (C) Representative infarct staining results of Myosin Cre⁺ mice and Ntn1^loxP/loxP Myosin Cre⁺ mice. The infarct area is outlined by a green line, and the blue line marks the AAR (scale bar = 1 mm). (D) cTnI levels of Myosin Cre⁺ mice compared with Ntn1^loxP/loxP Myosin Cre⁺ mice after surgery (n = 6 for Myosin Cre⁺, n = 5 for Ntn1^loxP/loxP Myosin Cre⁺; Mann-Whitney test). (E) Infarct sizes of Lyz2 Cre⁺ mice compared with Ntn1^loxP/loxP Lyz2 Cre⁺ mice after IR surgery (n = 5 for Lyz2 Cre⁺, n = 7 for Ntn1^loxP/loxP Lyz2 Cre⁺; two-tailed unpaired t test). (F) Representative infarct staining results of Lyz2 Cre⁺ mice and Ntn1^loxP/loxP Lyz2 Cre⁺ mice as described in C (scale bar = 1 mm). (G) cTnI levels of Lyz2 Cre⁺ mice compared with Ntn1^loxP/loxP Lyz2 Cre⁺ mice after surgery (n = 5 for Lyz2 Cre⁺, n = 7 for Ntn1^loxP/loxP Lyz2 Cre⁺; two-tailed unpaired t test). *, P < 0.05; **, P < 0.01. Data are presented as mean ± SD.