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. 2021 Apr 15;134(7):jcs254458. doi: 10.1242/jcs.254458

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© 2021. Published by The Company of Biologists Ltd

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Fig. 7. — GSEA of Lbh^−/− and Lbh^+/+ OHCs transcriptomes. Enriched pathways (FDR <0.25) Lbh^−/− null OHCs include regulation of Wnt signaling (A), Notch signaling (B), cell cycle (C), nucleic acid-templated transcription (D), DNA damage/repair (E) and autophagy (F). The total numbers of upregulated (red) and downregulated (green) genes within each pathway are indicated, and the top 20 genes in each category are listed on either side of the graph, with greatest to least fold change in downward direction (arrow). (G) Validation of differentially expressed cell survival genes using RT-qPCR. Log2 fold changes (Lbh^−/− versus Lbh^+/+) from RNA-seq and ΔΔCt values (normalized to Actb) from RT-qPCR for each gene are shown.