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. 2021 Apr 27;17(4):e10232. doi: 10.15252/msb.202110232

Figure 1. Single‐cell sequencing of SARS‐CoV‐2‐infected colon‐ and ileum‐derived human organoids.

Figure 1

  1. Schematic representation of the experimental workflow.
  2. Uniform manifold approximation and projection (UMAP) embedding of single‐cell RNA‐Seq data from mock and SARS‐CoV‐2‐infected colon‐derived (left panels) and ileum‐derived (right panels) organoids colored according to the cell type. Small insets highlight in the UMAP the cell from mock and infected organoids at 12 and 24 hpi (Red) and the rest of the cells (gray).
  3. Dot plot of the top marker genes for each cell type for (left) colon‐ and (right) ileum‐derived organoids. The dot size represents the percentage of cells expressing the gene; the color represents the average relative expression across the cell type.
  4. Bar plot displaying the proportion of each cell type in mock and infected organoids (12 and 24 hpi).