Table 3.

Changes (%) in the Spine, Total Hip, Femoral Neck and Whole Body Areal Bone Mineral Density With Testosterone Therapy According to rs1062033 and rs700518 Polymorphism of the CYP19A1.

Rs1062033	CC	CG	GG	P value
Spine
6 months	2.52 ± 0.62	1.59 ± 0.49	2.19± 0.82	0.42
12 months	3.38 ± 0.50b	1.58 ± 0.43	3.87± 0.76a	0.006
18 months	3.74 ± 0.63	2.85 ± 0.56	4.72 ± 0.91	0.19
Total Hip
6 months	0.70 ± 0.65	0.39 ± 0.56	−0.56 ± 0.98	0.52
12 months	0.42 ± 0.67	0.52 ± 0.58	−0.50 ± 1.06	0.69
18 months	0.64± 0.56	0.70 ± 0.50	0.33 ± 0.84	0.93
Femoral Neck
6 months	0.42 ± 0.87	−0.58 ± 0.75	0.39 ± 1.31	0.64
12 months	0.34 ± 0.74	−0.05 ± 0.67	−0.39 ± 1.19	0.74
18 months	0.22 ± 0.96	0.64 ± 0.81	−1.04 ± 1.31	0.52
Whole Body
6 months	0.31 ± 0.41	0.81 ± 0.34	1.75 ± 0.60	0.11
12 months	1.13 ± 0.39	0.47 ± 0.34	2.16 ± 0.60a,c	0.03
18 months	1.48 ± 0.46	1.38 ± 0.41	2.20± 0.67a,c	0.04
Rs700518	AA	AG	GG	P value
Spine
6 months	3.13 ± 0.62	1.57 ± 0.43	1.71 ± 0.75	0.10
12 months	3.26 ± 0.56	2.05 ± 0.41	2.96 ± 0.74	0.22
18 months	3.82 ± 0.70	4.13 ± 0.52	3.69 ± 0.87	0.95
Total Hip
6 months	0.45 ± 0.98	0.51 ± 0.52	−0.26 ± 0.73	0.70
12 months	0.30 ± 0.74	0.50 ± 0.56	−0.15 ± 1.11	0.85
18 months	0.08 ± 0.66	0.93 ± 0.49	0.38 ± 0.93	0.70
Femoral Neck
6 months	−0.42 ± 1.37	−0.12 ± 0.72	0.21 ± 1.01	0.92
12 months	0.18 ± 1.18	0.03 ± 0.61	−0.11± 0.82	0.97
18 months	−1.25± 0.91	1.51± 0.69d,e	−1.09 ±1.28	0.03
Whole Body
6 months	−0.02± 0.46	0.87 ± 0.30	1.63 ± 0.55f	0.04
12 months	1.02 ± 0.45	0.55 ± 0.31	2.08 ± 0.57f,d	0.05
18 months	1.16 ± 0.53	1.66 ± 0.38	2.22 ± 0.64	0.32

Data are expressed as Mean ± SD; BMD: bone mineral density; P values adjusted for age and BMI (body mass index);

^ap<0.05 GG vs. CG,

^bp<0.05 CC vs. CG,

^cp<0.05 GG vs. CC;

^dp<0.05 AG vs. GG,

^ep<0.05 AG vs. AA,

^fP<0.05 GG vs. AA