Table 4.

Changes (%) in Bone Volumetric Bone Mineral Density, Bone Geometry and Bone Structure by Peripheral Quantitative Computer Tomography at the 38% Tibia With Testosterone Therapy According to the rs1062033 and rs700518 Polymorphism of the CYP19A1.

Rs1062033	CC	CG	GG	Model 1 P value	Model 2 P value
6 months
Total density	−1.71 ± 1.14	1.66 ± 1.16	−0.30 ± 2.13	0.33	0.16
Total area	0.07 ± 0.97	−2.56 ± 0.99	−5.11 ± 1.81a	0.26	0.04
Total content	−1.69 ± 1.08	−1.11 ± 1.11	−5.56 ± 2.02	0.32	0.13
Cortical area	0.17 ± 0.58	−0.32 ± 0.59	−2.97 ± 1.08a,b	0.20	0.04
Cortical content	−1.49 ± 1.17	−0.46 ± 1.20	−5.09 ± 2.07	0.32	0.16
Cortical density	−1.74 ± 0.93	−0.14 ± 0.95	−2.18 ± 1.74	0.62	0.39
Cortical thickness	0.34 ± 0.79	1.88 ± 0.80	0.39 ± 1.47	0.34	0.37
Periosteal circumference	0.02 ± 0.49	−1.32 ± 0.50	−2.63 ± 0.91a	0.26	0.04
Endosteal circumference	−0.10 ± 1.26	−3.29 ± 1.28	−4.71 ± 2.34	0.33	0.15
18 months
Total density	−2.03 ± 0.97	−1.01 ± 0.96	−1.67 ± 1.78	0.79	0.77
Total area	0.65 ± 0.99	1.66 ± 0.98	−5.90 ± 21.72a,b	0.06	0.03
Total content	−1.42 ± 0.99	0.43 ± 0.98	−6.72 ± 1.72a,b	0.13	0.009
Cortical area	−0.11 ± 0.56	−0.14 ± 0.55	−3.69 ± 0.97a,b	0.07	0.007
Cortical content	−1.59 ± 1.09	−0.31 ± 1.13	−6.50 ± 1.92a,b	0.21	0.03
Cortical density	−1.56 ± 0.83	−0.16 ± 0.81	−2.88 ± 1.43	0.60	0.28
Cortical thickness	−0.58 ± 0.80	−1.30 ± 0.79	−0.01 ± 1.39	0.94	0.69
Periosteal circumference	0.30 ± 0.58	0.79 ± 0.59	−3.01 ± 1.01a,b	0.06	0.002
Endosteal circumference	1.12 ± 1.34	2.62 ± 1.35	−5.19± 2.33a,b	0.16	0.03
Rs700518	AA	AG	GG	Model 1 P	Model 2 P
6 months
Total density	−1.93 ± 1.36	1.44 ± 1.01	−1.17 ± 2.01	0.13	0.13
Total area	0.23± 1.26	−2.80 ± 0.94	−2.61 ± 1.87	0.36	0.15
Total content	−1.79 ± 1.33	−1.55 ± 0.99	−3.84 ± 1.97	0.92	0.56
Cortical area	−0.08 ± 0.80	−0.61 ± 0.59	−0.93 ± 1.18	0.91	0.78
Cortical content	−1.62 ± 1.46	−1.01 ± 1.09	−3.23 ± 2.16	0.83	0.63
Cortical density	−1.63 ± 1.10	−0.40 ± 0.82	−2.40 ± 1.63	0.80	0.45
Cortical thickness	−0.12 ± 0.99	1.70 ± 0.74	1.03 ± 1.47	0.17	0.33
Periosteal circumference	0.09 ± 0.64	−1.45 ± 0.48	−1.34 ± 0.94	0.35	0.15
Endosteal circumference	0.45 ± 1.62	−3.49 ± 1.21	−2.85 ± 2.40	0.20	0.15
18 months
Total density	−2.16 ± 1.13	−1.14 ± 0.86	−1.62 ± 1.67	0.88	0.78
Total area	0.22 ± 1.21	1.21 ± 0.91	−3.86 ± 1.78	0.53	0.07
Total content	−0.73 ± 1.59	0.49 ± 1.13	−2.72 ± 2.18	0.53	0.49
Cortical area	−0.44 ± 0.68	−0.44 ± 0.51	−1.62 ± 1.01	0.84	0.61
Cortical content	−2.06 ± 1.24	−0.73 ± 0.93	−4.73 ± 1.83	0.68	0.23
Cortical density	−1.71 ± 0.97	−0.28 ± 0.73	−3.21 ± 1.43	0.73	0.23
Cortical thickness	−1.36 ± 0.94	−0.67 ± 0.70	1.10 ± 1.38	0.75	0.35
Periosteal circumference	0.08 ± 0.60	0.56 ± 0.45	−1.94 ± 0.89	0.54	0.08
Endosteal circumference	0.89 ± 1.60	2.17 ± 1.22	−4.15 ± 2.35	0.44	0.11

Data are expressed as Mean ± SD; Model 1:adjusted for baseline age, baseline body mass index (BMI), Model 2: Model 1 plus appendicular lean mass

^ap<0.05 GG vs. CC,

^bp<0.05 GG vs. CG