Table 3.
Multivariate analysis of factors predicting 90-day mortality after hepatectomy
| Unadjusted HR (95% CI) | Unadjusted p value | Adjusted HR (95% CI) | Adjusted p value | |
|---|---|---|---|---|
| Alkaline phosphatase (units/L) | 1.004 (1.001–1,007) |
0.004 | 1.002 (0.997–1.006) |
0.504 |
| Gamma-glutamyl transferase (units/L) | 1.003 (1.001–1.004) |
<0.001 | 1.001 (0.998–1.003) |
0.661 |
| Child-Pugh class B/C |
2.55 (1.44–4.54) |
0.001 |
3.44 (0.152–0.557) |
<0.001 |
| Platelet-albumin-bilirubin (PALBI)1 | 1.417 (1.025–1.959) |
0.035 | 1.203 (0.771–1.876) |
0.415 |
| Prognostic nutritional index | 0.948 (0.917–0.979) |
0.001 | 0.977 (0.929–1.027) |
0.358 |
| Bilirubin/albumin ratio (µmol/g) | 1.921 (1.23–2.983) |
0.004 | 0.747 (0.318–1.754) |
0.503 |
| Neutrophil-to-lymphocyte ratio | 1.056 (0.994–1.122) |
0.076 | 1.013 (0.916–1.120) |
0.799 |
| Model for End-Stage Liver Disease (MELD) | 1.055 (0.993–1.1210 |
0.083 | 1.014 (0.942–1.092) |
0.708 |
| Indocyanine green | 1.828 (0.916–3.650) |
0.087 | 1.546 (0.643–3.716) |
0.330 |
| Operation time | 1.003 (1.001–1.004) |
0.005 | 0.999 (0.997–1.002) |
0.670 |
| Blood loss |
1.392 (1.083–1.790) |
0.010 |
1.486 (1.088–2.031) |
0.013 |
| PHLF criterion 1: 50/50 − bilirubin >50 µmol/L, INR >1.7 |
7.166 (2.853–18.002) |
<0.001 |
8.628 (3.330–22.353) |
<0.001 |
| PHLF criterion 2: peak serum bilirubin >119 µmol/L |
3.910 (1.941–7.878) |
<0.001 |
2.963 (1.355–6.480) |
0.007 |
| PHLF criterion 3: local laboratories: bilirubin >31 µmol/L, INR >1.4 |
2.177 (1.235–3.835) |
0.007 | 0.966 (0.396–2.357) |
0.940 |
Bold type denotes significance. PHLF, post-hepatectomy liver failure.
1
PALBI = 2.02 × log10 bilirubin − 0.37 × (log10 bilirubin) 2 − 0.04 × albumin − 3.48 × log10 platelets + 1.01 × (log10 platelets) [23].