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Comparison of kinase inhibitory effect on targeted molecule between lenvatinib and sorafenib
| IC50, nmol/L |
||
|---|---|---|
| lenvatinib | sorafenib | |
| VEGFR-1 | 4.7 | 21 |
| VEGFR-2 | 3 | 21 |
| VEGFR-3 | 2.3 | 16 |
| FGFR1 | 61 | 340 |
| FGFR2 | 27 | 150 |
| FGFR3 | 52 | 340 |
| FGFR4 | 43 | 3,400 |
| PDGFRα | 29 | 1.6 |
| PDGFRβ | 160 | 27 |
| RAF1 | 1,610 | 46.4 |
| BRAF | 8,660 | 314 |
VEGF, vascular endothelial growth factor. Bold character represents an inhibitory effect on each molecule. Modified from ref. [24].
