Fig. 3.

Transcriptomic differences between amniotic fluid monocytes/macrophages of predominantly fetal or maternal origin. a pORA and total pAcc showing KEGG pathway impact analysis between predominantly fetal (n = 3) and maternal (n = 3) amniotic fluid monocytes/macrophages. Significantly impacted pathways are shown in red. b Predicted activated and inhibited upstream regulators of DEGs in amniotic fluid monocytes/macrophages of predominantly fetal origin compared to those of predominantly maternal origin. c GO analysis using genes significantly downregulated in amniotic fluid monocytes/macrophages of predominantly fetal origin compared to those of predominantly maternal origin. The top 10 significantly enriched biological processes are shown. d STRING analysis showing a subset of genes downregulated in amniotic fluid monocytes/macrophages of predominantly fetal origin compared to those of predominantly maternal origin, represented as nodes in the network. The edges between nodes represent high-confidence protein-protein interactions for the corresponding genes. Red, “response to stimulus” network; blue, “developmental process” network; green, “cellular component organization” network; pORA, plot based on gene overrepresentation; pAcc, pathway accumulation; DEGs, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.