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Chelidonine induces caspase-3 cleavage with p53 pathway activation by upregulating GADD45a and p21 signaling in pancreatic cancer cells. (A) Treatment of chelidonine (0, 0.5, and 1 µM) for 24 hours increases p21, p53, GADD45A, and cleaved caspase-3 protein expression in BxPC-3 and MIA PaCa-2 cells. (B) The band density was quantified and normalized to β-actin.
*P < .05, **P < .01 and ***P < .001 versus non-treated cells.
