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Inhibition of p53 and GADD45a blocked caspase-3 cleavage by chelidonine treatment in pancreatic cancer cells. After gene expression inhibition with (A) si-p53 or (B) si-GADD45a, the protein expressional changes were analyzed by western blotting on chelidonine (0 and 1 µM) treated BxPC-3 and MIA PaCa-2 cells for 48 hours. (C), (D) The band density was quantified and normalized to β-actin.
***P < .001 versus non-treated cells.
