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The model assumes that there is a lineage-specific requirement for YY1 PcG function. YY1 PcG function is required for pre-B cell and early T cell development; however, it is not necessary for myeloid cells. YY1 regulates early T cell development via both PcG-dependent and PcG-independent mechanisms. Although early T cell survival relies on YY1 PcG function, YY1 regulates DN1-to-DN2 transition and Notch1 expression via its non-PcG function.
