Fig. 5.

Cellular lineages contributing to tendon and enthesis repair in mice. Injuries to the tendon and enthesis heal through the formation of a persistent fibrovascular scar that does not recapitulate the native morphology or mechanical properties of the original tissue. Cells contributing to tendon repair originate from the tendon proper (green cell) and the tendon sheath (orange cell), whereas cells contributing to enthesis healing can be sourced from either tendon or bone (beige cell). A few cell-specific markers that characterize putative tendon stem/progenitor cells (TSPCs) or enthesis stem/progenitor cells (ESPCs) have been identified. Asterisks indicate markers found in tendon sheath-derived cells.