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. 2021 Apr 15;14(4):dmm047662. doi: 10.1242/dmm.047662

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Global miRNA:miRNA interactions are due to the culmination of the reactions within the cell that control miRNA expression. These consider all direct and indirect changes in miRNA and mRNA expression in response to a perturbation in miRNA expression. Full comprehension of the complexity of miRNA:miRNA interactions in a cellular system involves the integration of several mechanisms, and the consideration of resultant secondary changes in miRNA and mRNA.