Table 3.
Summary of the presentation of 22 reported cases of HEM, NOS
| Characteristic | Most common findings |
|---|---|
| Sex (F/M) | 6/16 |
|
| |
| Age (range), years | 4–23 |
|
| |
| Most common clinical presentation | RUQ pain |
|
| |
| Most common imaging characteristic | A large solid tumor of the liver with peripheral enhancement and central necrosis |
|
| |
| AFP (range), ng/mL | 21,000–1,280,000 |
|
| |
| Pre-chemo pathology diagnosis | HEM, NOS: 13 |
|
| |
| HBL: 5 | |
|
| |
| nr: 4 | |
|
| |
| Post-chemo pathology diagnosis | HEM, NOS: 16 |
|
| |
| HCC-like: 2 | |
|
| |
| HBL: 1 | |
|
| |
| nr: 3 | |
|
| |
| Histological findings | Heterogeneous and complex with areas similar to HBL and areas similar to HCC |
|
| |
| Positive immunohistochemical markers | β-Catenin and glypican-3 |
|
| |
| Outcome (free of disease/died) | 14 (63.7%) |
HEM, NOS, hepatocellular malignant tumor, not otherwise specified; AFP, alpha-fetoprotein; HBL, hepatoblastoma; nr, not reported; HCC, hepatocellular carcinoma.