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. 2021 Apr 26;21:237. doi: 10.1186/s12935-021-01945-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Angiogenesis of PCa cells is blocked by overexpressed miR-129-5p or down-regulated ZIC2. DU-145 cells were treated with miR-129-5p mimic, miR-129-5p inhibitor or/and si-ZIC2. a The angiogenesis in each group; b the angiogenesis indexes in each group; c the protein expression of VEGF and CD31 in each group; d the statistical analysis of c. *p < 0.05 vs. the blank and NC groups. The data are summarized as mean ± standard deviation. The experiment was repeated three times and the data were compared using the one-way analysis of variance. VEGF vascular endothelial growth factor, GAPDH glyceraldehyde-3-phosphate dehydrogenase