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. 2021 Apr 26;18:99. doi: 10.1186/s12974-021-02149-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Neuropathological features of spinal cords in EAE mice treated with GAT107. Spinal cords of mice from the placebo- and GAT107-treated groups were removed at day 30 after EAE induction. a Treatment with GAT107 (10 mg/day) for 8 days improved CNS inflammation and reduced the number of EAE lesions. Representative images (with hematoxylin and eosin staining) at × 20 magnification are shown for the b placebo- and c GAT107-treated cells. The arrows indicate the foci (n = 6 in the placebo group and n = 7 in GAT107-treated group) (**p < 0.001)