TABLE 2.
Characteristics of treatment with previous MPH medications and DEX
| Previous MPH treatment | |
| Number of MPH therapies, n (%) (N=137) | |
| 1 | 118 (86.1) |
| 2 | 15 (11.0) |
| 3 | 3 (2.2) |
| 5 | 1 (0.7) |
| Number of single doses per day, mean ± SD (N=137) | 1.4 ± 0.5 |
| Immediate-release (N=33) | 1.5 ± 0.6 |
| Extended-release (N=114) | 1.4 ± 0.5 |
| Total daily MPH dose (mg), mean ± SD (N=137) | 27.5 ± 14.1 |
| Immediate-release (N=33) | 20.7 ± 12.2 |
| Extended-release (N=114) | 28.9 ± 14.0 |
| DEX treatment | |
| Total daily dose at the respective visit (mg), median (IQR) | |
| First titration visit (initial dose) (N=138) | 5.0 (5.0) |
| Children (<12 years) (N=80) | 5.0 (5.0) |
| Adolescents (≥12 years) (N=58) | 5.0 (5.0) |
| Titration (last recorded dose) (N=138) | 11.3 (10.0) |
| Children (<12 years) (N=80) | 10.0 (10.6) |
| Adolescents (≥12 years) (N=58) | 15.0 (10.0) |
| V2 (N=95) | 12.5 (10.0) |
| Children (<12 years) (N=57) | 10.0 (10.0) |
| Adolescents (≥12 years) (N=38) | 15.0 (10.0) |
| V3 (N=82) | 15.0 (10.0) |
| Children (<12 years) (N=53) | 12.5 (10.0) |
| Adolescents (≥12 years) (N=29) | 20.0 (10.0) |
| Optimal total daily dose (mg), median (IQR) (N=120) | 10.0 (10.0) |
| Children (<12 years) (N=69) | 10.0 (10.0) |
| Adolescents (≥12 years) (N=51) | 15.0 (10.0) |
| Optimal total daily dose per body weight (mg/kg), median (IQR) (N=120) | 0.3 (0.3) |
| Children (<12 years) (N=69) | 0.4 (0.3) |
| Adolescents (≥12 years) (N=51) | 0.3 (0.2) |
| Number of titration steps to optimal total daily dose, n (%) (N=140) | |
| 1 | 16 (11.4) |
| 2 | 46 (32.9) |
| 3 | 24 (17.1) |
| 4 | 22 (15.7) |
| 5 | 4 (2.9) |
| 6 | 7 (5.0) |
| 10 | 1 (0.7) |
| Optimal total daily dose not achieved | 18 (12.9) |
| No titration performed | 2 (1.4) |
| Dose regimen, n (%) (N=129) | |
| Once daily | 76 (58.9) |
| Twice daily | 50 (38.8) |
| Three times daily | 2 (1.6) |
| Four times daily | 1 (0.8) |
Notes. DEX: Dexamphetamine; IQR: Interquartile range; MPH: Methylphenidate; SD: Standard deviation