Table 3.
Univariable analysis of subjective evaluation of pre-operative PDAC imaging findings and therapy efficacy of S-1 in the primary cohort
| Non-response group (n = 16) | Response group (n = 15) | p value | |
|---|---|---|---|
| T1WI | 1.000 | ||
| Iso-intensity | 1 (6.3%) | 1 (6.7%) | |
| Mild hypo-intensity | 15 (93.8%) | 14 (93.3%) | |
| T2WI | 1.000 | ||
| Iso-/mild hypo-intensity | 7 (43.8%) | 7 (46.7%) | |
| Mild hyper-intensity | 9 (56.3%) | 8 (53.3%) | |
| Morphology | 0.037 | ||
| Regular | 9 (56.3%) | 14 (93.3%) | |
| Irregular | 7 (43.8%) | 1 (6.7%) | |
| Tumour margins on T2WI | 0.394 | ||
| Well defined | 2 (12.5%) | 4 (26.7%) | |
| Ill defined | 14 (87.5%) | 11 (73.3%) | |
| Tumour margins on T1WI | 0.473 | ||
| Well defined | 5 (31.3%) | 7 (46.7%) | |
| Ill defined | 11 (68.6%) | 8 (53.3%) | |
| Tumour margins after enhancement | 0.073 | ||
| Well defined | 6 (37.5%) | 11 (73.3%) | |
| Ill defined | 10 (62.5%) | 4 (26.7%) | |
| Peripheral delayed enhancement of tumour | 0.135 | ||
| Invisible | 13 (81.3%) | 8 (53.3%) | |
| Visible | 3 (18.8%) | 7 (46.7%) | |
| Central delayed enhancement of tumour | 0.473 | ||
| Invisible | 8 (50.0%) | 5 (33.3%) | |
| Visible | 8 (50.0%) | 10 (66.7%) | |
| Necrosis of tumour | 0.172 | ||
| Absence | 11 (68.8%) | 14 (93.3%) | |
| Presence | 5 (31.3%) | 1 (6.7%) | |
| Peripancreatic infiltration | 0.012 | ||
| Invisible | 4 (25.0%) | 11 (73.3%) | |
| Visible | 12 (75.0%) | 4 (26.7%) | |
| Peripancreatic blood vessel invasion | 1.000 | ||
| Invisible | 10 (62.5%) | 10 (66.7%) | |
| Visible | 6 (37.5%) | 5 (33.3%) | |
| Artery invasion | 0.654 | ||
| Invisible | 14 (87.5%) | 12 (80.0%) | |
| Visible | 2 (12.5%) | 3 (20.0%) | |
| Vein invasion | 0.704 | ||
| Invisible | 10 (62.5%) | 11 (73.3%) | |
| Visible | 6 (37.5%) | 4 (26.7%) | |
| Pancreatic duct dilatation | 0.704 | ||
| Absence | 6 (37.5%) | 4 (26.7%) | |
| Presence | 10 (62.5%) | 11 (73.3%) | |
| Atrophy of upstream pancreas | 0.458 | ||
| Absence | 9 (56.3%) | 11 (73.3%) | |
| Presence | 7 (43.8%) | 4 (26.7%) | |
| Retention cyst formation | – | ||
| Absence | 16 (100.0%) | 15 (100.0%) | |
| Presence | 0 (0.0%) | 0 (0.0%) |
Bold means statistically significant (p values < 0.05)