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. Author manuscript; available in PMC: 2021 Sep 23.
Published in final edited form as: Neuron. 2020 Jul 15;107(6):1124–1140.e11. doi: 10.1016/j.neuron.2020.06.027

Figure 1: Specific nucleoporins are altered in nuclei from C9orf72 iPSNs.

Figure 1:

(A-C) Maximum intensity projections from SIM imaging of Nups in nuclei isolated from control and C9orf72 iPSNs. Genotype and time point as indicated on left, antibodies as indicated on top. (D-E) Quantification of Nup spots and volume. Time point as indicated on top. N = 8 control and 8 C9orf72 iPSC lines (including 1 isogenic pair), 50 NeuN+ nuclei per line/time point. Two-way ANOVA with Tukey’s multiple comparison test was used to calculate statistical significance. **** p < 0.0001. Scale bar = 5 μm. * indicates significantly altered Nups.