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. Author manuscript; available in PMC: 2021 Sep 23.
Published in final edited form as: Neuron. 2020 Jul 15;107(6):1124–1140.e11. doi: 10.1016/j.neuron.2020.06.027

Figure 2. Specific nucleoporins are altered in nuclei from C9orf72 patient motor cortex.

Figure 2.

(A-B) Maximum intensity projections from SIM imaging of Nups in nuclei isolated from postmortem human brain tissue. Genotype and brain region as indicated on left, antibodies as indicated on top. (C-D) Quantification of Nup spots and volume. Brain region as indicated on top. N = 3 control and 3 C9orf72 cases, 50 NeuN+ nuclei per case. Two-way ANOVA with Tukey’s multiple comparison test was used to calculate statistical significance. **** p < 0.0001. Scale bar = 5 μm. * indicates significantly altered Nups.