| Methods |
Initiated as a double‐blind trial, but changed to a single‐blind |
| Participants |
The number of participants for the double‐blind part is not reported. In the single‐blind stage, 22 subjects were included "The majority were adults whose ages ranged from 30 to 50, with the extremes being five children younger than 12" (p 949) |
| Interventions |
For the double‐blind part: "ascorbic acid alone, ascorbic acid plus bioflavonoids, flavonoids only and, fourthly, a lactose placebo with the two 'vitamins' present either alone or together in 0.2 g quantities". In the single‐blind stage, 0.6 g of vitamin C was administered every 3 h |
| Outcomes |
Clinical progress (Table 7) |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Allocation method not described |
| Allocation concealment (selection bias) |
Unclear risk |
? |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
Initiated as double‐blind |
| Blinding of outcome assessment (detection bias)
All outcomes |
Unclear risk |
? |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
? |
| Vitamin C and placebo indistinguishable? |
Unclear risk |
"lactose placebo" |
