| Study | Reason for exclusion |
|---|---|
| Aigner 2018 | Wrong study design: observational |
| Aigner 2020 | Wrong study design: retrospective analysis |
| Al‐Akash 2012 | Wrong study design: subgroup analysis |
| Alpay 2019 | Wrong study design: retrospective analysis |
| Alsakran 2019 | Wrong study design: retrospective analysis |
| Bhalla 2019 | Wrong study design: retrospective analysis |
| Bohl 2016 | Wrong study population: haematopoietic stem cell transplantation‐associated TMA |
| Cao 2018 | Wrong study design: retrospective analysis |
| Cataland 2014 | Wrong study design: subgroup analysis |
| Cofiell 2015 | Wrong study outcomes: study designed to monitor the effect of eculizumab on multiple physiologic pathways affected by complement dysregulation in aHUS but does not measure the clinical outcomes included within this review |
| Escribano 2017 | Wrong study design: retrospective analysis |
| Favi 2018 | Wrong study population: transplant recipients |
| Fremeaux‐Bacchi 2015 | Wrong study design: review |
| Frykman 2016 | Wrong study design: observational |
| Galbusera 2019 | Wrong study design and outcomes: case‐series evaluating the efficacy of an ex‐vivo test for disease activity in aHUS during treatment |
| Gavriilaki 2015 | Wrong study design and outcomes: pre‐clinical study designed to develop a novel cell assay to distinguish aHUS from other TMA |
| Gomez‐Alvarez 2016 | Wrong study design: retrospective analysis |
| Gruppo 2011 | Wrong study design: retrospective analysis |
| Han 2019 | Wrong study design: case report |
| Hanes 2019 | Wrong patient population: healthy volunteers |
| Ito 2019 | Wrong study design: observational |
| Jozsi 2007 | Wrong study design and outcomes: pre‐clinical study examining the role of factor‐H autoantibodies in aHUS |
| Kant 2020 | Wrong study design: retrospective analysis |
| Kato 2019 | Wrong study design: observational |
| Khandelwal 2016 | Wrong study design: retrospective analysis |
| Khandelwal 2019 | Wrong study design: retrospective analysis |
| Khursigara 2014 | Wrong study design: retrospective analysis |
| Kumar 2019 | Wrong study design: retrospective analysis |
| Lappegard 2015 | Wrong study design: review |
| Legault 2009 | Wrong study design: case study |
| Levi 2016 | Wrong patient population: transplant recipients |
| Mazo 2017 | Wrong study design: retrospective analysis |
| Menne 2019 | Wrong study design and patient population: observational study reporting long‐term outcomes for patients previously treated with eculizumab in prospective studies. Participants not required to fulfil TMA criteria at enrolment in this trial |
| Monet‐Didailler 2020 | Wrong patient population: Shiga toxin‐producing E. coli HUS |
| Nayer 2016 | Wrong study design: review |
| Nester 2013 | Wrong study design: review |
| Nilsson 2007 | Wrong study design and outcomes: observational study designed to understand the role of factor I in complement regulation in patients with aHUS |
| Noris 2014 | Wrong study outcomes: designed to test new assays of complement activation and identify a tool for eculizumab titration |
| Pape 2016 | Wrong study design and patient population: observational study reporting long‐term outcomes for patients previously treated with eculizumab in prospective study. Participants not required to fulfil TMA criteria at enrolment in this trial |
| Pape 2017 | Wrong study design and patient population: observational study reporting long‐term outcomes for patients previously treated with eculizumab in prospective study. Participants not required to fulfil TMA criteria at enrolment in this trial |
| Picard 2015 | Wrong study design: review |
| Raina 2018 | Wrong study design: retrospective analysis |
| Siedlecki 2019 | Wrong study design: retrospective analysis |
| Simonetti 2011 | Wrong study design: retrospective analysis |
| Socie 2019 | Wrong study design: retrospective analysis |
| Taylor 2010 | Wrong study design: guideline |
| Ubago 2014 | Wrong study design: review |
| Uriol 2018 | Wrong study design: retrospective analysis |
| Vakiti 2019 | Wrong study design and patient population: case series; drug induced aHUS |
| Vilalta 2012 | Wrong study design: retrospective analysis |
| Vivarelli 2014 | Wrong study design: review |
| Volokhina 2016 | Wrong study outcomes: pharmacodynamics |
| Volokhina 2016a | Wrong study outcomes: pharmacodynamics |
| Walle 2017 | Wrong study design: observational |
| Walle 2017a | Wrong study design: retrospective analysis of pooled data |
| Weston‐Davies 2013 | Wrong patient population: healthy volunteers |
| Wijnsma 2016 | Wrong study design: case series |
| Wong 2015 | Wrong study design: review |
| Wuhl 2020 | Wrong study design: retrospective analysis |
aHUS ‐ atypical haemolytic uraemic syndrome; TMA ‐ thrombotic microangiopathy