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. 2001 Apr 23;2001(2):CD001499. doi: 10.1002/14651858.CD001499

Beller 1985.

Methods Design: 
 Double‐blind 
 randomized 
 placebo controlled 
 multiple phase crossover design (2 days x 4)
Order of dose conditions randomized separately for each patient
Participants Country: USA 
 Number: 8 inpatients in a geropsychiatric unit. 
 Sex: 4 males and 4 females 
 Age: 58‐83 years 
 Diagnosis Criteria: DSM III for PDD 
 Severity of AD: moderate to moderately severe Reisberg scores 3‐5 
 MIT scores 6‐13
Interventions 1. placebo 
 2. oral physostigmine 0.5 mg every 2 hours 7 doses per day (3.5 mg per day) 
 3. oral physostigmine 1.0 mg every 2 hours 7 doses per day (7.0 mg/day) 
 4. oral physostigmine 2.0 mg every 2 hours 7 doses per day (14.0 mg/day)
Outcomes BSRT 
 SCAG 
 BPRS 
 NOSIE
Notes Outcomes assessed on the second day of treatment.