Comparison 1. Orlistat: Anthropometric Outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Orlistat: Change in Weight (%)	13	6196	Mean Difference (IV, Random, 95% CI)	‐2.93 [‐3.35, ‐2.50]
2 Orlistat: Change in Weight (kg)	14	9457	Mean Difference (IV, Random, 95% CI)	‐2.87 [‐3.21, ‐2.53]
3 Orlistat: 5% Responders (absolute % difference)	14	9389	Risk Difference (M‐H, Random, 95% CI)	0.21 [0.18, 0.24]
4 Orlistat: 10% Responders (absolute % difference)	13	8857	Risk Difference (M‐H, Random, 95% CI)	0.12 [0.09, 0.14]
5 Orlistat: Change in Waist Circumference (cm)	9	4631	Mean Difference (IV, Random, 95% CI)	‐2.06 [‐2.86, ‐1.26]
6 Orlistat: Change in Body Mass Index (kg/m2)	3	1276	Mean Difference (IV, Random, 95% CI)	‐1.05 [‐1.40, ‐0.71]
7 Orlistat: Sensitivity Analysis According to Baseline CV Risk (Absolute Weight Loss)	15	9833	Mean Difference (IV, Random, 95% CI)	‐2.75 [‐3.13, ‐2.36]
7.1 Change in Weight in Lower Risk Population (kg)	7	6655	Mean Difference (IV, Random, 95% CI)	‐3.00 [‐3.59, ‐2.41]
7.2 Change in Weight in Higher Risk Population (kg)	8	3178	Mean Difference (IV, Random, 95% CI)	‐2.59 [‐3.16, ‐2.02]
8 Orlistat: Sensitivity Analysis According to Baseline CV Risk (% Weight Loss)	13	6196	Mean Difference (IV, Random, 95% CI)	‐2.93 [‐3.35, ‐2.50]
8.1 Change in Weight in Lower Risk Population (%)	6	3378	Mean Difference (IV, Random, 95% CI)	‐3.42 [‐4.01, ‐2.83]
8.2 Change in Weight in Higher Risk Population (%)	7	2818	Mean Difference (IV, Random, 95% CI)	‐2.68 [‐3.25, ‐2.11]