Comparison 6. Sibutramine: Anthropometric Outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Sibutramine: Change in Weight (%)	8	1725	Mean Difference (IV, Random, 95% CI)	‐4.34 [‐5.01, ‐3.67]
1.1 Weight Loss Studies	7	1536	Mean Difference (IV, Random, 95% CI)	‐4.54 [‐5.11, ‐3.96]
1.2 Weight Maintenance Studies	1	189	Mean Difference (IV, Random, 95% CI)	‐2.40 [‐4.44, ‐0.36]
2 Sibutramine: Change in Weight (kg)	10	2348	Mean Difference (IV, Random, 95% CI)	‐4.16 [‐4.73, ‐3.59]
2.1 Weight Loss Studies	7	1536	Mean Difference (IV, Random, 95% CI)	‐4.20 [‐4.77, ‐3.64]
2.2 Weight Maintenance Studies	3	812	Mean Difference (IV, Random, 95% CI)	‐4.01 [‐5.73, ‐2.28]
3 Sibutramine: 5% Responders (absolute % difference)	7	1464	Risk Difference (M‐H, Random, 95% CI)	0.32 [0.27, 0.37]
3.1 Weight Loss Studies	6	1304	Risk Difference (M‐H, Random, 95% CI)	0.32 [0.27, 0.38]
3.2 Weight Maintenance Studies	1	160	Risk Difference (M‐H, Random, 95% CI)	0.31 [0.18, 0.45]
4 Sibutramine: 10% Responders (absolute % difference)	7	1464	Risk Difference (M‐H, Random, 95% CI)	0.18 [0.11, 0.25]
4.1 Weight Loss Studies	6	1304	Risk Difference (M‐H, Random, 95% CI)	0.17 [0.10, 0.23]
4.2 Weight Maintenance Studies	1	160	Risk Difference (M‐H, Random, 95% CI)	0.31 [0.16, 0.45]
5 Sibutramine: Change in Waist Circumference (cm)	8	1837	Mean Difference (IV, Random, 95% CI)	‐3.99 [‐4.70, ‐3.28]
5.1 Weight Loss Studies	6	1237	Mean Difference (IV, Random, 95% CI)	‐3.97 [‐4.92, ‐3.03]
5.2 Weight Maintenance Studies	2	600	Mean Difference (IV, Random, 95% CI)	‐4.11 [‐5.52, ‐2.70]
6 Sibutramine: Change in Body Mass Index (kg/m2)	5	956	Mean Difference (IV, Random, 95% CI)	‐1.54 [‐1.79, ‐1.30]
7 Sibutramine: Sensitivity Analysis According to Baseline CV Risk (Absolute Weight Loss)	10	2348	Mean Difference (IV, Random, 95% CI)	‐4.16 [‐4.73, ‐3.59]
7.1 Change in Weight in Lower Risk Population (kg)	5	1470	Mean Difference (IV, Random, 95% CI)	‐3.99 [‐5.04, ‐2.95]
7.2 Change in Weight in Higher Risk Population (kg)	5	878	Mean Difference (IV, Random, 95% CI)	‐4.28 [‐4.97, ‐3.58]
8 Sibutramine: Sensitivity Analysis According to Baseline CV Risk (% Weight Loss)	8	1725	Mean Difference (IV, Random, 95% CI)	‐4.34 [‐5.01, ‐3.67]
8.1 Change in Weight in Lower Risk Population (%)	3	847	Mean Difference (IV, Random, 95% CI)	‐3.87 [‐5.68, ‐2.06]
8.2 Change in Weight in Higher Risk Population (%)	5	878	Mean Difference (IV, Random, 95% CI)	‐4.53 [‐5.23, ‐3.83]