| Methods |
Randomized, double‐blind, placebo‐controlled.
Weight maintenance trial. |
| Participants |
205 participants underwent 4 week VLCD. Those who lost 6 or more kg (n=160) were randomized for 1 y treatment. Mean age 38y. Mean BMI 35.5 kg/m2. Mean weight 104 kg.
France. |
| Interventions |
Sibutramine 10 mg daily (n=352). Attrition rate 34%.
Placebo (n=78). Attrition rate 42%. |
| Outcomes |
weight loss, % wieght maintenance, waist circumference, 5 and 10% responders, triglycerides, HDL chol, Total/HDL chol ratio, LDL chol, blood pressure, pulse rate |
| Notes |
Co‐intervention: diet counseling. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
