| Methods |
Randomized, double‐blind, placebo‐controlled.
Weight loss trial. |
| Participants |
531 patients with HTN, IGT or dyslipidemia. 1 year follow‐up. Mean age 46 y. Mean BMI 37.1 kg/m2. Mean weight 101 kg. UK. |
| Interventions |
Orlistat 120 mg tid (n=265). Attrition rate 30%.
Placebo (n=266). Attrition rate 40%. |
| Outcomes |
weight loss, 5% and 10% responders, BMI, waist circ, lipid profile, blood pressure, glucose, OGTT score |
| Notes |
Co‐interventions: 600‐900 kcal/d deficit diet, food diary |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
