| Methods |
Randomized, double‐blind, placebo‐controlled.
Weight loss trial. |
| Participants |
228 patients followed for 1 year. Mean age 41 y. Mean BMI 36.8 kg/m2. Mean weight 98 kg. UK. |
| Interventions |
Orlistat 120 mg tid (n=114). Attrition rate 36%.
Placebo (n=114). Attrition rate 42%. |
| Outcomes |
weight loss, 5% and 10% responders, waist circ, lipid profile, blood pressure, glucose, insulin |
| Notes |
Co‐interventions: 600‐900 kcal/d deficit diet |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
