| Methods |
Randomized, double‐blind, placebo‐controlled.
Weight loss trial. |
| Participants |
322 patients with DM2 followed for 1 year. Mean age 55 y. Mean BMI 34.3 kg/m2. Mean weight 100 kg. US. |
| Interventions |
Orlistat 120 mg tid (n=63). Attrition rate 15%.
Placebo (n=159). Attrition rate 28%. |
| Outcomes |
weight loss, 5% and 10% responders, waist circ, lipid profile, apolipoproteins, A1c, glucose, insulin |
| Notes |
Co‐interventions: 500 kcal/d deficit diet. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
