| Methods |
Randomized, double‐blind, placebo‐controlled.
Weight loss trial. |
| Participants |
696 patients followed for 18 months. Mean age 41 y. Mean BMI 36.1 kg/m2. Mean weight 97 kg. France. |
| Interventions |
Orlistat 120 mg tid (n=346). Attrition rate 35%.
Placebo (n=350). Attrition rate 43%. |
| Outcomes |
weight loss, waist circ, lipid panel, A1c, glucose, blood pressure |
| Notes |
Co‐intervention: 20% energy reduced diet increased by 10% if weight stable; food diary |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
