| Methods |
Randomized, double‐blind, placebo‐controlled.
Weight loss trial. |
| Participants |
194 patients with DM2. 52 week follow‐up. Mean age 49 y. Mean BMI 36.6 kg/m2. Mean weight 103 kg. UK, Canada, France, Belgium. |
| Interventions |
Sibutramine 15 mg daily (n=68). Attrition rate 28%.
Sibutramine 20 mg daily (n=62). Attrition rate 21%.
Placebo (n=64). Attrition rate 28%. |
| Outcomes |
weight loss, 5% and 10% responders, BMI, waist circ, waist‐hip ratio, lipid profile, A1c, glucose, insulin, blood pressure, heart rate |
| Notes |
Co‐intervention: diet counseling |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
