| Methods |
Randomized, double‐blind, placebo‐controlled.
Weight loss trial. Second year weight maintenance. |
| Participants |
688 patients followed for 1 year with a second weight maintenance year. Mean age 45 y. Mean BMI 36.1 kg/m2. Mean weight 100 kg. Europe. |
| Interventions |
Orlistat 120 mg tid (n=345). Attrition rate 17%.
Placebo (n=343). Attrition rate 20%. |
| Outcomes |
weight loss, 5% and 10% responders, lipids, glucose, insulin, blood pressure |
| Notes |
Co‐interventions: 600‐900 kcal/d deficit diet |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
