Smith 2001.

Methods	Randomized, double‐blind, placebo‐controlled. Weight loss trial.
Participants	485 patients from primary care. 52 week follow‐up. Mean age 42 y. Mean BMI 32.7 kg/m2. Mean weight 87 kg. UK.
Interventions	Sibutramine 10 mg daily (n=161). Attrition rate 42%. Sibutramine 15 mg daily (n=161). Attrition rate 49%. Placebo (n=163). Attrition rate 51%.
Outcomes	weight loss, 5% and 10% responders, BMI, waist circ, waist‐hip ratio, total cholesterol, triglycerides, glucose, uric acid, blood pressure, heart rate
Notes	Co‐intervention: diet counseling
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate