| Study | Randomization OK | Allocation Conceal | Baseline Similarity | Eligib Crit Spec | Patient Blinded | Care Provider Blind | Outcome Assess Blind | Primary Outcome Rep | ITT Analysis |
| RIO‐Diabetes | Y | Y | Y | Y | Y | Y | ? | Y | N |
| RIO‐Europe | Y | Y | Y | Y | Y | Y | ? | Y | N |
| RIO‐Lipids | N | N | Y | Y | Y | Y | ? | Y | N |
| RIO‐NA | ? | ? | Y | Y | Y | Y | ? | Y | N |
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