Seal 2002.

Methods	Randomized double‐blind placebo‐controlled trial
Participants	Country: Australia Number: 31 randomized Age: mean 81.4 years Inclusion Criteria: serum B12 level < 150 pmol/L , the majority living at home Exclusion criteria: Pernicious anaemia, history of malabsorption, vitamin B12 treatment or supplementation 6: dropped‐out
Interventions	1. Placebo 2. Oral cyanocobalamin in two doses: 10 and 50 microgram daily for 1 month
Outcomes	MMSE Serum vitamin B12/folate/Hcy
Notes	3 people had diabetes mellitus type II
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate

MMSE: Mini Mental State Examination 
 ADAS: Alzheimer's Disease Assessment Scale 
 CAMCOG: Cambridge Cognitive Examination 
 MDI: Major Depression Inventory 
 P‐MMA: Plasma Methylmalonic Acid