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. 2021 Apr 23;100(16):e25552. doi: 10.1097/MD.0000000000025552

Figure 3.

Figure 3

(A) Kaplan–Meier plots of overall survival according to LINE-1 methylation level in 77 hepatocellular carcinoma (HCC) patients divided into quartiles Q1–4: Overall survival was higher in Q1 than in Q2, Q3, and Q4. Q1 represents the “hypermethylation group” and a combination of Q2, Q3, and Q4 represents the “hypomethylation group.” (B) Kaplan–Meier plots of overall survival according to LINE-1 methylation level in 77 HCC patients. The survival rate was lower in patients with LINE-1 hypomethylation (median 36.2 months) than those with LINE-1 hypermethylation (median 44.6 months), although not statistically significant (log-rank test: P = .102). (C) Kaplan–Meier plots of progression-free survival according to LINE-1 methylation level in 77 HCC patients. The progression-free survival rate had a tendency to be lower in patients with LINE-1 hypomethylation (median 8.1 months) than those with LINE-1 hypermethylation (median 19.5 months), which showed borderline statistical significance (log-rank test: P = .075). HCC = hepatocellular carcinoma, LINE-1 = long interspersed nuclear element-1.