1. Tests in range.

	Mean INR within target range, %			TIme within range, %
Source			P value			P value
White 1989	68	87	< 0.001	‐	‐	‐
Horstkotte 1998	22.3	43.2	< 0.001	‐	‐	‐
Sawicki 1999	43.2	53	0.22	‐	‐	‐
Beyth 2000	‐	‐	‐	32	56	< 0.001
Cromheecke 2000	49	55	0.06	‐	‐	‐
Sidhu 2001	58	67.60	< 0.0001	63.8	76.5	< 0.0001
Fitzmaurice 2002	66 (61‐71)*	72 (65‐80)*	NS	77 (67‐86)*	74 (67‐81)*	NS
Gadisseur 2003 Self mge; Gadisseur 2003 Self monit	61.3	65	0.14	‐	‐	‐
Gardiner 2005	‐	‐	‐	64 (26)	61 (20)	NS
Kaatz Unpublished	54.2	64.6	< 0.05	66.9	63.5	0.127
Sunderji 2004	58.7 (5.8)**	64.8 (5.9)**	0.23	63.2 (5.8)**	71.8 (5.5)**	0.14
Khan 2004	‐	‐	‐	70.4 (24.5)**	71.1 (14.5)**	NS
Körtke 2001	60.5	78.3	< 0.001	‐	‐	‐
Voller 2005	58.5 (19.8)**	67.8 (17.6)**	0.0061	‐	‐	‐
Menendez‐Jandula 2005	55.6 (19.6)**	58.6% (14.3)**	0.02	64.9 (19.9)	64.3 (14.3)	0.2
Fitzmaurice 2005	‐	‐	‐	68 (65.2‐70.6)	70 (68.1‐72.4)	NS
Christensen 2006, Denmark	‐	‐	‐	68.9 (59.3‐78.2)	78.7 (69.2‐81.0)	NS
Siebenhofer 2007, Austria†	57.1 (40.4‐72.4)	72.4 (53.5‐79.4)	< 0.001	66.5 (47.1‐81.5)	75.4 (59.4‐85.0)	< 0.029
Azarnoush 2009	‐	‐	‐	61.5	55.5	0.0343
Christensen 2011	‐	‐	‐	79.9	72.7	< 0.0001
Grunau 2011	82.4	80.2	0.82	82.2	89.7	0.76
Matchar 2010	‐	‐	‐	66.2	62.4	< 0.001
Rasmussen 2012	‐	‐	‐	Intervention A 49 Intervention B 55	55	NS
Soliman Hamad 2009	72.9	53.9	0.01	‐	‐	‐
Thompson 2013	‐	‐	‐	52	45	0.05
Verret 2012	‐	‐	‐	80	75.5	0.79

* 95% Confidence intervals

** Standard Deviations

^† Used median not mean