Menendez‐Jandula 2005.

Study characteristics
Methods	Single centre, randomised controlled trial.
Participants	Participants (n=737) were ambulatory adults aged > 18 (mean 66) years, receiving long‐term anticoagulation therapy for > before the study for at least 3 months. The study was based in a University Hospital (Barcelona, Spain).
Interventions	Self‐management vs usual care Participants were randomised to: a) self‐management (n = 368): home self‐testing using the Coagucheck® ,self‐adjustment of dosage of oral anticoagulant, and self‐determination of time to next INR test. b) usual care (n = 369): visited the hospital for every four weeks to have their INR checked.
Outcomes	Primary outcomes: percentage of INR values within target range; time within target range. Secondary outcomes: major thromboembolic or haemorrhagic complications; minor bleeding; death.
Trial identification	ACOA
Study duration	Up to 17 months
Oral anticoagulant used	Warfarin or acenocoumarol
Notes	Training: two 2‐hour sessions in consecutive days run by a trained nurse.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Centralised telephone randomisation.
Allocation concealment (selection bias)	Low risk	The sequence of randomisation was concealed until the participant was assigned to a group.
Intention to treat analysis	Low risk	ITT analysis was used
Reporting of losses of follow‐up	Unclear risk	11.9% of participants were lost to follow‐up; reasons not reported.
Blinding	Low risk	Blinded outcome assessors.