Rasmussen 2012.

Study characteristics
Methods	Single‐centre, parallel‐group, randomised controlled study.
Participants	Participants were individuals requiring oral anticoagulation therapy (n = 54).
Interventions	Self‐monitoring vs usual care Participants were randomised to self‐testing with computer aided decision making, two different algorithms (computer algorithm group A n = 19, computer algorithm group B n = 18), or to usual care (monitoring and treatment by physicians) (n = 17).
Outcomes	Time to therapeutic range, time in therapeutic range, INR.
Trial identification
Study duration	Mean 28 week follow‐up
Oral anticoagulant used	Warfarin
Notes	Authors reported that there were insufficient data to provide valid measurements of thromboembolic events and severe bleeding. in this study it is difficult to estimate the individual effects of self‐testing and of computer dosage calculation.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomisation was performed by computer.
Allocation concealment (selection bias)	Unclear risk	Allocation concealment was not reported.
Intention to treat analysis	Unclear risk	ITT not reported.
Reporting of losses of follow‐up	Unclear risk	Losses to follow‐up were not reported.
Blinding	Low risk	Study investigators were blinded to computer algorithm group A vs group B allocation; statisticians were blinded to allocation.