FIG 3.

Overview of patient-matched molecular cohort. (A) Flowchart describing assembly of paired molecular cohort composed of patients with truly relapsed medulloblastomas and those with other subsequent CNS malignancies. (B) Methylation and next-generation sequencing data availability for each arm of the paired molecular cohort. (C) Subgroup and entity classification of patient-matched tissue from diagnosis and relapse. (D) Novel Groups 3 and 4 and (E) SHH subtype classifications of patient-matched tissue from diagnosis and relapse. EWS, Ewing sarcoma; HGG, high-grade glioma; iSHH, infant SHH; MB, medulloblastoma; NGS, next-generation sequencing; SHH, sonic hedgehog; WES, whole-exome sequencing; WNT, wingless.