FIG 5.

Subgroup divergence at medulloblastoma relapse. (A) Scatterplot depicting Group 3 and 4 classification scores for patients (n = 5) with divergent subgroup at relapse. (B) Oncoprint depicting alterations among patients with diagnostic group 4 tumors experiencing Group 3 relapse. A patient with primary Group 4 primary tumor (C) who experienced relapse with a Group 3 tumor (D) coincident with focal amplification of MYCN. G3, Group 3; G4, Group 4; MB, medulloblastoma; NGS, next-generation sequencing; SNV, single nucleotide variant.