FIG 6.

High-grade gliomas subsequent to primary medulloblastoma. (A) Classification scores of primary medulloblastomas and subsequent high-grade gliomas. (B) Oncoprint depicting patient characteristics and driver gene alterations for patient-matched tumor pairs with available next-generation sequencing (n = 6 patients). (C) Compartment-specific patterns of chromosome arm copy number variation for patient-matched tumor pairs (n = 8 patients). A patient with primary Group 4 tumor (D) who experienced subsequent high-grade glioma (E) in the local tumor bed. MRI, magnetic resonance imaging. HGG, high-grade glioma; MB, medulloblastoma; SHH, sonic hedgehog; SNV, single nucleotide variant; WES, whole-exome sequencing; WNT, wingless.