White 1999.

Methods	Randomized double‐blind placebo‐controlled crossover study 2 x 4 weeks separated by a 2 week washout period
Participants	Country: USA 8 participants (3 male 5 female) diagnosis: probable Alzheimer's disease NINCDS‐ADRDA criteria mild to moderate dementia MMSE 10‐26 mean 19 (5) Exclusion : uncontrolled hypertension cardiac disease stroke renal insufficiancy seizure syncope alcohol or drug abuse active skin disease sensitivity to medical dressings major depression tacrine or donepezil liver disease Parkinson's disease
Interventions	1. placebo patch 2. nicotine patch (Nicotrol) (5mg/day for 1 week , 10mg/day for 2 weeks, 5mg/day for the 4th week)
Outcomes	ADAS‐Cog ADL PDS CGI ANAM
Notes