Study	Reason for exclusion
Jones 1992	This study was not double‐blind and no method of randomization was specified.
Knott 2000	This study was confounded: 6 out of 13 were receiving a cholinesterase inhibitor. No method of randomization was stated and it was unclear whether it was double blinded.
Knott 2002	Single‐dose, pseudo‐randomized cross‐over design
Newhouse 1988	Single‐blind and not randomized
Newhouse 1990	Not double‐blind or randomized
Parks 1994	The study is not randomized. AD patients compared with normal controls.
Sahakian 1989	Single‐blind study, placebo‐controlled study. No randomization
Sahakian 1994	Single‐blind, placebo‐controlled study. No randomization
Snaedel 1996	Two studies reported: First was an open trial with an unsatisfactory method of randomization. In the second trial, there is no mention of randomization and the design is unclear from the details available.
White 2004	The study population did not suffer from AD but AAMI. Cross‐over design with no data from the first phase
Wilson 1995	No mention of randomization. Cross‐over design with no data from the first phase