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. 2010 Jan 20;2010(1):CD007693. doi: 10.1002/14651858.CD007693.pub2

Holt 1994.

Methods RCT conducted in non‐fluoridated areas in UK.
Participants 1099 out of the potential 2177 children aged 9 years old (who participated in the trial at 2 years old for a period of 3 years) gave positive consent to the follow‐up study.
Interventions Group 1: Fluoride toothpaste (550 ppm) (n = 568). 
 Group 2: Fluoride toothpaste (1000 ppm) (n = 531).
A sample of children who did not participate in the trial formed a third group and not included in this review.
Outcomes TFI. 
 DDE Index. 
 Both assessed from photographic digital images.
Notes Intra‐ and inter‐examiner reliability for TFI (Kappa = 0.68 and 0.78 respectively).
Data for the third group not used within this review.