Lattanzio 2015.

Study characteristics
Study design	Cohort
Study setting	Setting: Department of Neurosurgery, Santa Croce University Hospital, Cuneo Country: Italy Dates: tissue collected between 2006 and 2013
Selection of participants	People with newly diagnosed GBM and treated with standard TMZ‐containing chemoradiotherapy protocols
Participant characteristics	Sample size: 46 (deaths: 29) Age: median 64.5; range 24–84 years Sex: 76.1% men KPS: NR
Tumour characteristics	GBM: 100% First diagnosis: 100% Biopsy: NR; subtotal resection: NR; total resection: NR IDH1 wild‐type: NR; IDH2 wild‐type: NR
Treatment regimen	Standard TMZ‐containing chemoradiotherapy protocols
MGMT promoter methylation tests implemented	MSP, PSQ
Dates and follow‐up	Timing of MGMT assessment: for each participant, 2 samples of the primary tumour obtained: 1 collected during surgery, immersed in RNA later (Life Technologies, Carlsbad, CA, USA) and immediately snap‐frozen in liquid nitrogen, and 1 assembled from biopsy in FFPE sections using standard procedures. Start time for follow‐up: date of first surgery; follow‐up: median 7.4 months; range NR
Notes