Examples of ZIKV and DENV structural elements with m6A consensus motifs. (A) Two contiguous m6A-containing regions in the NS5 coding sequence of ZIKV MR766 genome (yellow and light pink circles) were identified in the reported secondary structure [14,21,121,123]. The nucleosides in predicted DRACH and MGACK m6A consensus motifs are circled in red and black, respectively. The RNA strand making intramolecular long-range interaction with prM coding region is indicated in grey. (B, C) Two different methylated regions of DENV2 NGC strain (yellow circles) were mapped within two independent reported structures in the NS3 coding sequence of the closely related strain DENV2 S16803 [14,21,121,123]. The nucleosides in predicted DRACH m6A consensus motifs are circled in red. In B, the DRACH motif is located in a 14 nucleotide-long stem flanked by unstructured regions whose SHAPE reactivity (indicated in grey) changed if vRNA was gently extracted from virions