Figure 5.

Silencing lncRNA NEAT1 suppresses the expression of miR-129 and miR-204 to inhibit FLS proliferation and synovitis in RA rats. (A) The thickness of rat paws upon inhibition of miR-129 or miR-204. (B) Arthritis score of rats upon inhibition of miR-129 or miR-204. (C) Western blot analysis of ERK1/2 and P38 MAPK expression and the extent of ERK1/2 and P38 MAPK phosphorylation normalized to GAPDH in synovial tissues upon inhibition of miR-129 or miR-204 and overexpression of LncRNA NEAT1. * p < 0.05 vs. rats treated with inhibitor NC. The data were expressed as mean ± standard deviation and analysed using one-way analysis of variance and repeated measures analysis of variance. The experiment was repeated three times independently